Introduction The pharmaceutical industry is undergoing rapid transformation, driven by regulatory expectations, technological advancements, and the need for cost-effective drug development. Traditional approaches to formulation development often relied on trial-and-error methodologies, leading to batch inconsistencies and regulatory hurdles. Quality by Design (QbD) provides a structured, science-based approach to ensure drug product quality, process robustness, and regulatory compliance. The adoption of QbD principles in pharmaceutical formulation is now a necessity to meet FDA, ICH Q8, and EMA guidelines while ensuring better patient outcomes and manufacturing efficiency. Understanding Quality by Design (QbD) QbD is defined by the International Conference on Harmonisation (ICH…

The Indian Pharmacopoeia (IP) has undergone significant development since its inception, reflecting the advancements in pharmaceutical sciences, regulatory standards, and healthcare needs in India. Below is an overview of its historical evolution: 1. Pre-Colonial and Early Colonial Era Before the formal establishment of the Indian Pharmacopoeia, traditional medicinal systems like Ayurveda, Unani, and Siddha dominated healthcare in India. However, with British colonial rule, Western medicine and pharmacopoeial standards became prominent. 2. British Era: Introduction of Western Pharmacopoeias 3. The First Indian Pharmacopoeia (1955) 4. Subsequent Editions and Updates 5. 21st Century: Modernization and Global Standards 6. Role of the Indian…

Cancer treatment has long been focused on targeting rapidly dividing cells, but recent research is uncovering a new and exciting frontier in oncology: the mitochondria. Known as the “powerhouse of the cell,” mitochondria are now recognized for their critical role in cancer progression, offering new therapeutic possibilities. This article explores how targeting mitochondria can revolutionize cancer therapy and provide novel approaches to combating this complex disease. The Role of Mitochondria in Cancer Cells Mitochondria are essential organelles responsible for energy production through oxidative phosphorylation. In healthy cells, they regulate metabolism, energy production, and apoptosis (programmed cell death). However, in cancer…

Metallo-betalactamase is a powerful opponent that scientists have uncovered in the ongoing war against antibiotic resistance. This unusual enzyme poses a serious risk to public health around the globe since it has the capacity to render several popular antibiotics useless. Now let’s explore the intriguing realm of metallo-betalactamase and how it relates to antibiotic treatment. The class of enzymes known as metallo-betalactamases (MBLs) is generated by specific bacteria and confers resistance to betalactam antibiotics, a wide class of antimicrobial drugs that includes carbapenems, cephalosporins, and penicillins. MBLs differ from other betalactamase enzymes in that they require metal ions, including zinc,…

Pharmacy software and technology are essential for improving medication management procedures, maintaining patient care, and optimizing operations in the quickly changing healthcare environment of today. At PharmacyFact, we understand how important it is to keep up with the most recent developments in pharmacy technology. Let’s investigate pharmacy software in more detail. Pharmacy Management Systems: These all-inclusive software programs are made to automate and simplify a number of different parts of running a pharmacy. Pharmacy operations may be made more accurate and efficient with the help of PMS platforms, which offer a variety of features ranging from inventory management and prescription…

Research is essential for advancing pharmacy practice, from examining new treatment modalities to enhancing medication safety. Come along as we showcase a few recent, ground-breaking studies that are influencing pharmacy’s future: Precision Medicine in Oncology: With the introduction of precision medicine, pharmacists are leading the way in customizing cancer therapies based on the genetic profiles of individual patients. Finding biomarkers that forecast medication response and resistance has been the focus of recent cancer pharmacy research. This allows for customized treatment plans that optimize effectiveness while reducing side effects. These developments could completely change the way cancer is treated and lead…